REPRODUCTIVE HISTOLOGICAL ALTERATIONS INDUCED DUE TO MALATHION EXPOSURE IN FEMALE ALBINO MICE
Sudhir Kumar Kataria* and Shefali
Department of Zoology, Maharshi Dayanand University, Rohtak, Haryana, 124001, India.
[Corresponding author E-mail*: firstname.lastname@example.org]
Received: 16-09-2015 Accepted: 20-10-2015
The state of Haryana is an agrarian state which is adjacent to National Capital Territory, New Delhi and is also known as rice bowl of the country to meet food requirement. Further to enhance food production pesticides are inevitably used and may results in exposure to non target organisms including human beings. Malathion is an organophosphorus insecticide widely used in public health, residential, and agricultural practices. In present study, we investigated the histological alterations caused by orally administered dose of Malathion (761.5mg/kg b.w.which is 50% of LD50), Cyclophosphamide (40mg/kg of b.w.) and distilled water. Malathion and Cyclophosphamide exposure results in loss of primordial and primary follicles degenerated ovarian tissue, albuminous fluid in graafian follicle and change in corpus luteum as compared to negative control which reveals the toxic effects of drug. So it should be used with prescribed precautions in the interest of healthy sustenance of generations of non target organisms.
Keywords: rice bowl, Malathion, agricultural practices, ovarian tissue, graafian follicle, mice