COMPARATIVE STUDY OF ULTRASTRUCTURAL CHANGES IN THE SYNOVIUM OF OSTEOARTHRITIS AND RHEUMATOID ARTHRITIS

Deepti Bhatt, Amit Kumar Verma, Rameez Hasan, Shahbaz Khan, Vassiuddin Khan, Syed Mansoor Ali and Kapil Dev*


Department of Biotechnology, Jamia Millia Islamia, New Delhi, India
*corresponding author email: kdev@jmi.ac.in, smansoor@jmi.ac.in
Received: 27-11-2018 Revised:04-12-2018 Accepted: 06-12-2018

Abstract
Rheumatoid arthritis (RA) is chronic, systemic and autoimmune inflammatory joint disease which causes cartilage and bone destruction leading to ultrastructural alterations. Therefore, it is important to study ultrastructural changes for diagnosis of the disease. Osteoarthritis (OA) and RA synovium was obtained from patients undergoing total knee replacement surgery. Electron microscopic blocks were formed for performing transmission electron microscopy (TEM) to study ultrastructural changes in synovium of OA and RA. OA tissues demonstrated mostly the necrosed area, no perivascular infiltration and well stacked collagen fibers. Whereas, RA tissues showed the presence of activated type A synoviocytes, type B synoviocytes, plasma cells and siderosomes. Ultrastructural findings in RA tissue showed severe inflammation than in OA tissues. These observations may play an important role as diagnostic criteria for arthritis.
Keywords: Osteoarthritis, rheumatoid arthritis, Synovium, Transmission electron microscopy

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